{"id":2005,"date":"2025-09-28T12:14:00","date_gmt":"2025-09-28T12:14:00","guid":{"rendered":"https:\/\/sitefansalaran.ir\/En\/?p=2005"},"modified":"2025-09-28T12:14:00","modified_gmt":"2025-09-28T12:14:00","slug":"new-scientific-breakthrough-in-increasing-liver-transplant-success","status":"publish","type":"post","link":"https:\/\/sitefansalaran.ir\/En\/2025\/09\/28\/new-scientific-breakthrough-in-increasing-liver-transplant-success\/","title":{"rendered":"New scientific breakthrough in increasing liver transplant success"},"content":{"rendered":"<p style=\"text-align: justify;\">-Researchers may have found a way to improve success rates of liver transplantation with a workaround for a well-known complication that can cause the new organ to fail, a study in mice suggests.<\/p>\n<p style=\"text-align: justify;\">The liver\u2019s blood supply is cut off when it is removed from the donor. When the blood supply is restored during transplantation into the recipient, the influx sparks inflammation that damages the liver, causing so-called ischemia-reperfusion injury.<\/p>\n<p style=\"text-align: justify;\">The resulting cascade of cellular and molecular events can lead to graft dysfunction and failure.<\/p>\n<p style=\"text-align: justify;\">In previous experiments, the researchers discovered that a protein called CEACAM1 helps protect the liver from injury during the transplantation process.<\/p>\n<p style=\"text-align: justify;\">In their latest study, published in JCI Insights, they discovered that CEACAM1 and another protein called Human Antigen R (HuR) together act as protective switches that prevent ischemia-reperfusion injury.<\/p>\n<p style=\"text-align: justify;\">They also found a way to boost these switches in mice, increasing their protective effect and reducing the damaging stress on the liver.<\/p>\n<p style=\"text-align: justify;\">The researchers also found the same protective relationship between HuR and CEACAM1 in discarded human livers that had been deemed unsuitable for transplantation.<\/p>\n<p style=\"text-align: justify;\">\u201cOne of the most intractable problems in the field of organ transplantation remains the nationwide shortage of donor livers, which has led to high patient mortality while waiting for a liver transplant,\u201d study leader Kenneth Dery from the David Geffen School of Medicine at UCLA said in a statement.<\/p>\n<p style=\"text-align: justify;\">\u201cThis could ultimately help address the national transplant shortage and lower mortality rates.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>-Researchers may have found a way to improve success rates of liver transplantation with a workaround for a well-known complication that can cause the new organ to fail, a study in mice suggests. The liver\u2019s blood supply is cut off when it is removed from the donor. When the blood supply is restored during transplantation [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":2006,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[38],"tags":[581],"class_list":{"0":"post-2005","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-sitefansalaran-original-articles","8":"tag-new-scientific-breakthrough-in-increasing-liver-transplant-success"},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v24.7 (Yoast SEO v25.4) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>New scientific breakthrough in increasing liver transplant success - sitefansalarn<\/title>\n<meta name=\"description\" content=\"New scientific breakthrough in increasing liver transplant success\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sitefansalaran.ir\/En\/2025\/09\/28\/new-scientific-breakthrough-in-increasing-liver-transplant-success\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New scientific breakthrough in increasing liver transplant success\" \/>\n<meta property=\"og:description\" content=\"New scientific breakthrough in increasing liver transplant success\" \/>\n<meta property=\"og:url\" content=\"https:\/\/sitefansalaran.ir\/En\/2025\/09\/28\/new-scientific-breakthrough-in-increasing-liver-transplant-success\/\" \/>\n<meta property=\"og:site_name\" content=\"sitefansalarn\" \/>\n<meta property=\"article:published_time\" content=\"2025-09-28T12:14:00+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/sitefansalaran.ir\/En\/wp-content\/uploads\/2025\/09\/photo_2025-09-28_15-45-10.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"975\" \/>\n\t<meta property=\"og:image:height\" content=\"553\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"dorost\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"dorost\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/sitefansalaran.ir\/En\/2025\/09\/28\/new-scientific-breakthrough-in-increasing-liver-transplant-success\/\",\"url\":\"https:\/\/sitefansalaran.ir\/En\/2025\/09\/28\/new-scientific-breakthrough-in-increasing-liver-transplant-success\/\",\"name\":\"New scientific breakthrough in increasing liver transplant success - 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